What is pain and where does it come from? Pain is an output from the brain, it is a real experience that is always unique to that individual, and is dependent on meaning, which is always context-dependent. It relies on biology, ecology, psychology, and sociology! Furthermore, the output of pain depends on past experiences, perspectives, the internal and external environment, emotions, and predictions. Even though it is an output from the brain, pain can be experienced anywhere in the body regardless of the presence or absence of tissue or structural damage. But is pain really all your head then? In this article, we will break down this simple yet complex question to help you better understand where pain comes from as well as pain science!